Gene information
Official symbol ADRA2A
Official full name adrenoceptor alpha 2A
Gene type protein-coding gene
Chromosome10q25.2
Alias symbolADRAR
Previous symbolADRA2; ADRA2R
Gene familyAdrenoceptors
Resources
Entrez Gene 150
HGNC HGNC:281
Ensembl ENSG00000150594
Vega OTTHUMG00000019050
UCSC uc001kzo.4
GO terms: 52 records
GO Description Category LogP Number of genes Detail
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0007264 small GTPase mediated signal transduction GO Biological Processes -2.76738893 22 More
GO:0007586 digestion GO Biological Processes -7.00342423 19 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0014069 postsynaptic density GO Cellular Components -1.43397325 8 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0022600 digestive system process GO Biological Processes -8.16734280 17 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0032279 asymmetric synapse GO Cellular Components -1.40063776 8 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045732 positive regulation of protein catabolic process GO Biological Processes -6.83749864 15 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
Drug-Gene interaction
view
Related drugs: 71 records
Drug name Interaction type Source PMID View
alseroxylon antagonist ChemblInteractions view
amphetamine TEND view
apraclonidine agonist TdgClinicalTrialTENDTTD 1574855016921219126303351693559314575724178241391757234317139284170164232039993411481271 view
apraclonidine hydrochloride agonist ChemblInteractions view
asenapine antagonist TdgClinicalTrial 18308814 view
atenolol PharmGKB 15614026 view
benzphetamine agonist TdgClinicalTrialTEND 254999571713928417016423 view
bethanidine agonist TdgClinicalTrialTEND 19627982545383 view
brimonidine agonist DTCTdgClinicalTrialTENDPharmGKBTTD 137317916407989107996491175235211481271 view
brimonidine tartrate agonist ChemblInteractions view
chembl10332 DTC 16407989 view
chembl1257057 DTC 16407989 view
clonidine agonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 15306201164079891475714011752127110824571209861412357167 view
clonidine hydrochloride agonist ChemblInteractions view
debrisoquin TdgClinicalTrialTEND view
dexmedetomidine agonist TdgClinicalTrialTENDPharmGKBTTD 15306201118346171458373911752127211044431769274815087625 view
dexmedetomidine hydrochloride agonist ChemblInteractions view
dipivefrin agonist TdgClinicalTrialTEND 215246491713928417016423 view
dipivefrin hydrochloride agonist ChemblInteractions view
dopamine DTCPharmGKB 16407989 view
droxidopa agonist ChemblInteractions 113067202117385018680204 view
epinephrine agonist TdgClinicalTrialChemblInteractionsPharmGKB 11306720613452918064417198023610742288186802049836297 view
epinephrine bitartrate agonist ChemblInteractions view
ergoloid mesylates antagonist ChemblInteractions view
esmirtazapine antagonist TdgClinicalTrial 26047892 view
esmirtazapine maleate antagonist ChemblInteractions view
fadolmidine TTD view
fadolmidine hydrochloride agonist ChemblInteractions view
fenoldopam antagonist TEND 76707371713928417016423 view
fipamezole TdgClinicalTrialTTD view
guanabenz agonist TdgClinicalTrialTENDTTD 790338588195078263811152656369050980 view
guanabenz acetate agonist ChemblInteractions view
guanfacine agonist TdgClinicalTrialTEND 20331927135679415928018111640651094284817173664 view
guanfacine hydrochloride agonist ChemblInteractions view
hydroxyamphetamine hydrobromide agonist ChemblInteractions view
isoproterenol PharmGKB view
labetalol hydrochloride antagonist ChemblInteractions view
levonordefrin agonist ChemblInteractions 19326476 view
lofexidine agonist TdgClinicalTrialTENDTTD 10598217135706410882840 view
medetomidine TTD view
meperidine TTD view
mephentermine sulfate agonist ChemblInteractions view
methamphetamine agonist TdgClinicalTrial 12453616955176915955613 view
methyldopa agonist TdgClinicalTrialChemblInteractionsTEND 1748597692844271041592617139284136332217016423145573738743022 view
methyldopate hydrochloride agonist ChemblInteractions view
mianserin antagonist TdgClinicalTrialTEND 16814817 view
milnacipran PharmGKB view
mirtazapine antagonist TdgClinicalTrialChemblInteractionsTEND 1193134490078381252349214628003116070478930006194011641193971310793320 view
moxonidine agonist DTCTTD 1502861616407989779108710217548 view
naphazoline hydrochloride agonist ChemblInteractions view
nicergoline TTD view
norepinephrine agonist DTCTdgClinicalTrialTENDPharmGKB 1130672016407989180644171980236171392841074228818680204170164239836297 view
norepinephrine bitartrate agonist ChemblInteractions view
olanzapine antagonist TdgClinicalTrial 17848919 view
oxymetazoline partial agonistagonist DTCTdgClinicalTrialTENDTTD 789211217164433164079891327384 view
oxymetazoline hydrochloride agonist ChemblInteractions view
pardoprunox TdgClinicalTrial view
phenoxybenzamine hydrochloride antagonist ChemblInteractions view
phentolamine antagonist DTCTdgClinicalTrialTEND 617679875626401098827312721093162733451640798912770936171150691346768 view
phentolamine mesylate antagonist ChemblInteractions view
phenylpropanolamine agonist TdgClinicalTrialTEND 171392841560808517016423 view
pseudoephedrine agonist TdgClinicalTrialTEND 17139284170164237507588 view
rauwolfia serpentina antagonist ChemblInteractions view
rauwolscine antagonist DTC 16407989 view
senrebotase TdgClinicalTrial view
tetrahydrozoline hydrochloride agonist ChemblInteractions view
tizanidine agonist TdgClinicalTrialTENDTTD 8930173193936912584947315481719 view
tizanidine hydrochloride agonist ChemblInteractions view
tolazoline hydrochloride antagonist ChemblInteractions view
trazodone antagonist TEND 1365657785521717139284170164233016788 view
yohimbine antagonist DTCTdgClinicalTrialTENDPharmGKBTTD 17558432105061651259109316407989163258001766402210611634 view
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
NC_000010.10:g.[112835159A>G;112836503C>G;112837073C>G;112837538G>A;112838552C>G;112838892C>A;112839282T>A;112839579C>T;g.112839601C>A;113042093G>T] genomics hyperglycemia[prognosis (bad)] acute myocardial infarction Adefurin A et al. Int J Cardiol. 2016
NC_000010.10:g.[112835159A>G;112836503C>G;112837073C>G;112837538G>A;112838552C>G;112838892C>A;112839282T>A;112839579C>T;g.112839601C>A;113042093G>T] genomics hyperglycemia[prognosis (bad)] acute myocardial infarction Adefurin A et al. Int J Cardiol. 2016
NC_000010.11:g.111282335T>G genomics hyperglycemia[prognosis (bad)] acute myocardial infarction Adefurin A et al. Int J Cardiol. 2016
NG_012020.1:g.4714G>C genomics hyperglycemia[prognosis (bad)] acute myocardial infarction Adefurin A et al. Int J Cardiol. 2016
All rights reserved: Soochow University Center for Systems Biology